WS20.4 Is lung clearance index (LCI) affected by the severity of lung disease in CF?

Is Lung Clearance Index (LCI) Affected by the Severity of Lung Disease in CF?

Background: LCI has been proven an effective tool in the detection of lung disease in CF. Objectives: a) To assess the correlation of ventilation inhomogeneity indices with structural damages of the lung, among different groups of disease severity and b) To compare the associations among MBW parameters with spirometry and CT. Method: Forty-four children and adolescents with CF participated in t...

Lung clearance index in CF: a sensitive marker of lung disease severity.

Lung Clearance Index and HRCT are complementary markers of lung abnormalities in young children with CF.

RATIONALE High resolution computed tomography (HRCT) is a more sensitive tool for detecting early cystic fibrosis (CF) lung disease than either spirometry or plain radiography, but its relationship to other measures of lung function has not been established in young children. OBJECTIVES (1) To assess whether the lung clearance index (LCI) derived from multiple breath inert-gas washout (MBW) i...

Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function.

BACKGROUND AND AIMS Sensitive outcome measures to assess the efficacy of therapeutic interventions in patients with cystic fibrosis (CF) with mild lung disease are currently lacking. Our objective was to study the ability of the lung clearance index (LCI), a measure of ventilation inhomogeneity, to detect a treatment response to hypertonic saline inhalation in paediatric patients with CF with n...

"Lung sparing growth": is the lung not affected by malnutrition?

Malnutrition is a major cause of mortality and morbidity in developing countries [1]. It has been reported to play a role in different acute and chronic disease conditions [2–4], including respiratory diseases and lung development [5, 6]. Starting in utero, maternal malnutrition during pregnancy may influence postnatal lung function directly (e.g. through decreased alveolar number), or indirect...